CoStudy

HomeCertificationsNCLEX-PN › Pharmacological Therapies

Pharmacological Therapies — NCLEX-PN practice questions

19 multiple-choice questions and 5 flashcards on Pharmacological Therapies, about 12% of the NCLEX-PN bank. Every one carries a written rationale.

Written and maintained by Nick Burton · last updated 2026-08-22 · how we write and review questions

What this chapter covers

Pharmacological Therapies is one of 8 chapters in CoStudy's NCLEX-PN bank, and it holds 19 of the bank's 162 multiple-choice questions — roughly 12% of the total. That proportion is not arbitrary: chapters follow the certifying body's published exam outline, and the number of questions in each is set by that domain's published weight, so the share of your practice time this chapter takes matches the share of the real exam it accounts for.

Studying by chapter is worth doing once you have a diagnostic score. A single overall percentage tells you whether you are close; it does not tell you which domain is dragging. Working a weak chapter in isolation, and re-testing it in isolation, is the fastest way to move a score that has stalled — and it is why the mock exams in CoStudy report by domain rather than as one number.

Free Pharmacological Therapies practice questions

9 questions drawn from this chapter, with the full rationale shown — the controlling principle behind the right answer, and why each wrong option tempts and fails.

A patient is to receive 1,000 mL of 0.9% NaCl over 8 hours. The infusion pump should be set at:

  1. 50 mL/hr
  2. 100 mL/hr
  3. 125 mL/hr
  4. 200 mL/hr

Answer: C — 125 mL/hr

1,000 / 8 = 125 mL/hr. A,B) Too slow. C) Correct. D) Too fast.

A patient on warfarin asks about diet. The LPN should reinforce:

  1. Eliminate all leafy greens
  2. Increase alcohol intake
  3. Eat large amounts of spinach
  4. Keep vitamin K intake consistent from day to day

Answer: D — Keep vitamin K intake consistent from day to day

A) Unrealistic and unnecessary. D) Correct — consistency, not avoidance, stabilizes INR. C) Sudden increase lowers INR. B) Alcohol increases bleeding risk.

Digoxin toxicity is suggested by:

  1. Increased appetite and energy
  2. Polyuria
  3. Severe rash
  4. Visual halos, nausea, bradycardia

Answer: D — Visual halos, nausea, bradycardia

A) Toxicity decreases appetite. D) Correct — yellow-green halos, anorexia, nausea, bradycardia are classic signs. Check level (therapeutic 0.5-2 ng/mL). C) Not characteristic. B) Not specific.

A subcutaneous injection should be given at which angle for an average-build adult?

  1. 15 degrees
  2. 45 to 90 degrees depending on needle length and tissue
  3. 90 degrees only with a 1.5-inch needle
  4. Intradermal at 5 degrees

Answer: B — 45 to 90 degrees depending on needle length and tissue

A) Intradermal angle. B) Correct — short needle 90 degrees, longer needle 45 degrees. C) Wrong needle length. D) Different route.

Which insulin has the FASTEST onset?

  1. Lispro
  2. Regular
  3. NPH
  4. Glargine

Answer: A — Lispro

A) Correct — lispro (rapid-acting) onsets in ~15 minutes. B) Short-acting, onsets in ~30 minutes. C) Intermediate. D) Long-acting, peakless.

A patient asks why insulin cannot be taken orally. The LPN explains:

  1. It tastes bad
  2. Gastric acids and digestive enzymes destroy it before absorption
  3. The pancreas would absorb it
  4. Oral insulin is the standard

Answer: B — Gastric acids and digestive enzymes destroy it before absorption

A) Not the reason. B) Correct — insulin is a peptide destroyed by GI digestion; must be parenteral. C) Not the mechanism. D) Not available routinely.

A patient is to receive vancomycin IV piggyback. The LPN should observe for which infusion-related reaction?

  1. Flushing of the face, neck, and upper torso (infusion reaction historically called 'red man')
  2. Hypertensive crisis
  3. Hyperkalemia
  4. Polyuria

Answer: A — Flushing of the face, neck, and upper torso (infusion reaction historically called 'red man')

A) Correct — histamine-mediated reaction with rapid infusion; slow infusion mitigates. B,C,D) Not characteristic.

Before administering digoxin, the LPN should:

  1. Check the patient's blood pressure only
  2. Take radial pulse for 15 seconds
  3. Give immediately
  4. Take the apical heart rate for 1 full minute; hold and notify provider if under 60 bpm in an adult

Answer: D — Take the apical heart rate for 1 full minute; hold and notify provider if under 60 bpm in an adult

A) Insufficient. D) Correct — apical for 60 seconds, hold for HR <60. C) Skips safety check. B) Not the standard for digoxin.

When mixing NPH and regular insulin in one syringe, the LPN should:

  1. Draw NPH first, then regular
  2. Draw regular (clear) first, then NPH (cloudy)
  3. Draw in any order
  4. Never mix

Answer: B — Draw regular (clear) first, then NPH (cloudy)

A) Wrong order risks contamination of regular vial. B) Correct — 'clear before cloudy' to keep the rapid/short-acting vial uncontaminated by NPH. C) Order matters. D) Allowed for some combinations.

Pharmacological Therapies flashcards

4 cards from the 5 in this chapter.

Insulin onset/peak/duration: Regular insulin (rapid-short)?

Onset 30 min, peak 2-4 hr, duration 6-8 hr.

Always check before giving any med:

Allergies, expiration, label x3, correct patient (2 identifiers), correct route.

Common warfarin teaching — diet?

Maintain CONSISTENT vitamin K intake (greens). Sudden changes affect INR.

Common digoxin toxicity signs?

Visual changes (halos, yellow vision), anorexia, nausea, bradycardia.

Practise the full chapter

These are a sample. The full Pharmacological Therapies chapter runs 24 items with per-chapter progress tracking, on the web and in the iOS app.

Open NCLEX-PN in CoStudy →

Other NCLEX-PN chapters

All NCLEX-PN practice questions →